A small study appearing in the journal Headache (2006; 46(5): 788-93) looked at the effect taking an antioxidant supplement had on 12 migraine sufferers. The subjects were patients who had not responded to other migraine treatments, including beta blockers, 5-hydroxytrptamine receptor agonists or other medication. They were given ten capsules per day of a  supplement containing vitamin C (60 mg), vitamin E (30 IU) and a pine bark extract (120 mg) for three months. Three months prior to receiving the supplementation the subjects filled out the migraine disability assessment questionnaire (MIDAS). At the end of three months of treatment they filled out the questionnaire again. There was a mean improvement of 50.6% in the MIDAS score. The subjects had fewer days with headaches and the headaches were less severe.

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